Instructions: the pharmacist is authorized to order and dispense the following antiviral agents to a patient that meets the evaluation inclusion criteria unless an identified contraindication applies for the patient.
- Oral Oseltamivir (Tamiflu)
- Contraindications
- Known hypersensitivity to oseltamivir or any component
- Patients 18 years and older with CrCl < 10 mL/min.
- If the pharmacist is unable to obtain a current CrCl for a patient with a history of chronic kidney disease (i.e., creatinine clearance (CrCl) < 60 mL/min, reduced kidney function, etc.), then the patient should be excluded from receiving Tamiflu.
- For purposes of this Protocol, current CrCl means a lab value obtained within the past six months and documented by a physician’s office, laboratory, or patient electronic health record, or reported by the patient and the pharmacist determines in their clinical judgment the patient report is accurate. The pharmacist shall document this information in the patient record.
- Dosing – all doses to be administered x 5 days
- Patients 18 years and older: 75 mg twice daily
- Patients 18 years and older with renal impairment
- CrCl > 60 mL/min: no dosage adjustment necessary
- CrCl 30 to 60 mL/min: 30 mg twice daily
- CrCl 10 to 30 mL/min: 30 mg once daily
- Oral Baloxavir Marboxil (Xofluza)
- Contraindications
- Known hypersensitivity to baloxavir or any component
- Weight < 40 kg
- Dosing – all doses to be administered as a single dose
- Weight-based
- 40 kg to < 80 kg: 40 mg
- 80 kg and above: 80 mg
- Inhaled Zanamivir (Relenza Diskhaler)
- Contraindications
- Known hypersensitivity to zanamivir or any component (contains milk proteins)
- Underlying respiratory disease or asthma
- Dosing – all doses to be administered twice daily x 5 days
- 10 mg (two 5 mg inhalations)
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