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Practice Compounding Prescription - Suppository
 
Roberta Roberts
5050 Plaza Hill Road
3/22/20XX
Aspirin 100 mg
Fattibase Q.S.
M & Ft. Rectal Suppository
Dispense: 15
Sig: 1 pr Q6H prn fever
NR
Cynthia McDonald
BM1854911
1402 Hillcrest Road
Additional Information:
  • Calculate for 5 extra suppositories.
  • Use Plastic Suppository Shells
  • Plastic Shell Calibration with Fattibase = 1.9 grams
  • Source of Aspirin = Aspirin 325 mg Tablets
  • The average weight of an Aspirin 325 mg tablet is 390 mg
  • DDF for Aspirin in Fattibase = 1.3
  • DDF for all Excipients in Fattibase = 1
Calculations:
  • Total weight (g) of aspirin needed to compound 20 suppositories (15 + 5 extra) = g
     
  • Number of aspirin tablets needed to crush =
     
  • Weight (g) of crushed aspirin tablet powder needed (use average tablet weight info) = g
     
  • Weight (g) of excipient in required amount of aspirin crushed tablet powder = g
     
  • Weight (g) of Fattibase displaced by aspirin (use DDF) = g
     
  • Weight (g) of Fattibase displaced by excipient (use DDF) = g
     
  • Total weight (g) of 20 suppositories using plastic shells (use calibration) = g
     
  • Actual amount (g) of Fattibase to weigh (subtract displaced amounts from total) = g
     

Procedure:
  1. Prepare plastic suppository shells by positioning them upright in a wooden suppository rack. Be sure to inspect the shells for any deformities.
     
  2. Place aspirin tablets in glass mortar and perform with a pestle until a fine powder is obtained.
     
  3. Weigh g of crushed aspirin tablet powder.      
     
     
  4. Using a grater, grate an excess amount of Fattibase into small, consistently sized shavings.
     
  5. Weigh g of Fattibase shavings.      
     
     
  6. Place the aspirin powder into a sieve that is in a medium weigh boat.
     
  7. Place the Fattibase shavings into a 100 mL glass beaker.
     
  8. Place the glass beaker containing the Fattibase on a hot plate and begin melting it using a heat setting.
     
  9. Once melted, turn off the heat, add a stir bar and begin stirring the base using a rate.
     
  10. Sift the aspirin powder into the molten base with continuous stirring until all the mixture has been added.
     
  11. Carefully remove the beaker and product from the heat source, place it on the countertop and begin stirring it continuously with a glass rod allowing the mixture to cool for 3-4 minutes at room temperature. Must be able to hold comfortably in your hand.
     
  12. Carefully, yet quickly, pour the mixture into the center of each suppository shell cavity filling to the
     
  13. Allow the poured suppositories to congeal and harden at room temperature for at least
     
  14. Once the suppositories have set, remove the plastic suppository shell from the suppository and trim to correct length using a razor blade.
     
  15. Transfer 15 suppositories to a suppository box.
     
  16. Appropriately discard excess.
     
  17. Label and dispense.
     

 
 

Calculations Grade:      
 
Procedure Grade: